Novel Isotypic γ/ζ Subunits Reveal Three Coatomer Complexes in Mammals
نویسندگان
چکیده
منابع مشابه
Biochemical heterogeneity and phosphorylation of coatomer subunits.
The coat protomer complex I (COPI) family of coat proteins are involved in the assembly of membrane-associated coats thought to mediate vesicular transport between the endoplasmic reticulum and the Golgi complex, between adjacent Golgi cisternae, and possibly in the endocytic pathway. We investigated whether this heterogeneity in the sites of COPI action might be reflected in biochemical hetero...
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Arginine (R)-based ER localization signals are sorting motifs that confer transient ER localization to unassembled subunits of multimeric membrane proteins. The COPI vesicle coat binds R-based signals but the molecular details remain unknown. Here, we use reporter membrane proteins based on the proteolipid Pmp2 fused to GFP and allele swapping of COPI subunits to map the recognition site for R-...
متن کاملA Structure-Based Mechanism for Arf1-Dependent Recruitment of Coatomer to Membranes
Budding of COPI-coated vesicles from Golgi membranes requires an Arf family G protein and the coatomer complex recruited from cytosol. Arf is also required with coatomer-related clathrin adaptor complexes to bud vesicles from the trans-Golgi network and endosomal compartments. To understand the structural basis for Arf-dependent recruitment of a vesicular coat to the membrane, we determined the...
متن کاملDifferential localization of coatomer complex isoforms within the Golgi apparatus.
Coatomer, the coat protein of coat protein complex (COP)I-vesicles, is a soluble protein complex made up of seven subunits, alpha-, beta-, beta'-, gamma-, delta-, epsilon-, and zeta-COP. Higher eukaryotes have two paralogous versions of the gamma- and zeta- subunits, termed gamma1- and gamma2-COP and zeta1- and zeta2-COP. Different combinations of these subunits are known to exist within coatom...
متن کاملIsotypic Decompositions of Lattice Determinants
The q; t-Macdonald polynomials are conjectured by Garsia and Haiman to have a representation theoretic interpretation in terms of the Sn-module M spanned by the derivatives of a certain polynomial (x1; x2; : : : ; xn; y1; y2; : : : ; yn). The diagonal action of a permutation 2 Sn on a polynomial P = P (x1; x2; : : : ; xn; y1; y2; : : : ; yn) is de ned by setting P = P (x 1 ; x 2 ; : : : ; x n; ...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2004
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.24.3.1070-1080.2004